Ciprofloxacin hydrochloride hydrate

Research use only, not for human use.

Ciprofloxacin hydrochloride hydrate is a fluoroquinolone antibioticis an antibiotic used to treat a number of bacterial infections.

Ciprofloxacin hydrochloride hydrate is a fluoroquinolone antibioticis an antibiotic used to treat a number of bacterial infections.(In Vitro):Ciprofloxacin (Bay-09867) hydrochloride monohydrate (5-50 μg/mL; 0-24 h; tendon cells) inhibits cell proliferation and causes cell cycle arrest at the G2/M phase.Ciprofloxacin (Bay-09867) hydrochloride monohydrate shows potent activity against Y. pestis and B. anthracis with MIC90 of 0.03 μg/mL and 0.12 μg/mL, respectively.(In Vivo):Ciprofloxacin (Bay-09867) hydrochloride monohydrate (30 mg/kg; i.p.; for 24 hours; BALB/c mice) has protection against Y. pestis in murine model of pneumonic plague.Ciprofloxacin (Bay-09867) hydrochloridemonohydrate (100 mg/kg; i.g.; daily, for 4 weeks; C57BL/6J mice) accelerates aortic root enlargement and increases the incidence of aortic dissection and rupture by decreases LOX level and increases MMP levels and activity in the aortic wall.Ciprofloxacin (Bay-09867) hydrochloride monohydrate (100 mg/kg; i.g.; daily, for 4 weeks; C57BL/6J mice) induces DNA damage and release of DNA to the cytosol, mitochondrial dysfunction, and activation of cytosolic DNA sensor signaling. Ciprofloxacin lactate increases apoptosis and necroptosis in the aortic wall.

Ciprofloxacin (Bay-09867) hydrochloride monohydrate (5-50 μg/mL; 0-24 h; tendon cells) inhibits cell proliferation and causes cell cycle arrest at the G2/M phase.Ciprofloxacin (Bay-09867) hydrochloride monohydrate shows potent activity against Y. pestis and B. anthracis with MIC90 of 0.03 μg/mL and 0.12 μg/mL, respectively.Cell Viability Assay Cell Line:Tendon cells Concentration:5, 10, 20 and 50 μg/mL Incubation Time:24 hours Result:Decreased the cellularity of tendon cells.Cell Cycle Analysis Cell Line:Tendon cellsConcentration:50 μg/mL Incubation Time:24 hours Result:Arrested cell cycle at the G2/M phase and inhibited cell division in tendon cells.Western Blot Analysis Cell Line:Tendon cells Concentration:50 μg/mL Incubation Time:0, 6, 12, 17 and 24 hours Result:Down-regulated the expression of CDK-1 and cyclin B protein and mRNA. Up-regulatedthe expression of PLK-1 protein.

Ciprofloxacin (Bay-09867) hydrochloride monohydrate (30 mg/kg; i.p.; for 24 hours; BALB/c mice) has protection against Y. pestis in murine model of pneumonic plague.Ciprofloxacin (Bay-09867) hydrochloride monohydrate (100 mg/kg; i.g.; daily, for 4 weeks; C57BL/6J mice) accelerates aortic root enlargement and increases the incidence of aortic dissection and rupture by decreases LOX level and increases MMP levels and activity in the aortic wall.Ciprofloxacin (Bay-09867) hydrochloride monohydrate (100 mg/kg; i.g.; daily, for 4 weeks; C57BL/6J mice) induces DNA damage and release of DNA to the cytosol, mitochondrial dysfunction, and activation of cytosolic DNA sensor signaling. Ciprofloxacin lactate increases apoptosis and necroptosis in the aortic wall. Animal Model:BALB/c mice Dosage:30 mg/kg Administration:Intraperitoneal injection; for 24 hours Result:Reduced the lung bacterial load in murine model of pneumonic plague.Animal Model:C57BL/6J mice Dosage:100 mg/kg Administration:Oral gavage; daily, for 4 weeks Result:Had aortic destruction that was accompanied by decreased LOX expression and increased MMP expression and activity.Animal Model:C57BL/6J mice Dosage:100 mg/kg Administration:Oral gavage; daily, for 4 weeks Result:Caused mitochondrial DNA and nuclear DNA damage, leading to mitochondrial dysfunction and ROS production. Increased apoptosis and necroptosis in the aortic wall.

Bay-09867 hydrochloride monohydrate | Ciloxan | Ceprimax | Oftacilox

GPCR/G Protein

Antibacterial

Bacterial

Inflammation/Immunology

Infections of the genitourinary system respiratory tract gastrointestinal tract

86393-32-0

385.8

C17H21ClFN3O4

>98% (HPLC)

DMSO:8 mg/mL (20.74 mM)H2O:10 mg/mL (25.92 mM)

Cl.O.O=C(O)c1cn(C2CC2)c2cc(N3CCNCC3)c(F)cc2c1=O

1-Cyclopropyl-6-fluoro-4-oxo-7-piperazin-1-ylquinoline-3-carboxylic acid hydrate hydrochloride

(-20℃)

With Ice Pack

≥ 2 years